Primer to the Immune Response: Academic Cell Update Edition by Tak W. Mak;Mary E. Saunders

Author:Tak W. Mak;Mary E. Saunders [Saunders, Tak W. Mak;Mary E.]
Language: eng
Format: epub
Published: 2012-06-16T01:27:00+00:00

iii) MALT in the Eye

The conjunctiva and anterior ocular surface of the eye are particularly delicate tissues. Thus, as discussed in Chapter 10, the eye is an immune-privileged site in which immune responses and inflammation are generally discouraged. Cells and macromolecules cannot readily pass through the walls of the blood vessels supplying the eye, and the eye is not connected to a draining lymph node. Antigens that do access the eye are captured by intraocular APCs (including specialized subsets of DCs) that have been influenced by the high concentrations of TGE(3 present in the aqueous humor of the eye to promote Th2 development. The intraocular APCs migrate from the eye into the blood and thence to the spleen, where lymphocyte activation occurs. Effector Th2 cells home back to the eye where they support non-inflammatory antibody responses.

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